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KMID : 0191120230380010009
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Journal of Korean Medical Science
2023 Volume.38 No. 1 p.9 ~ p.9
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Vaccine Effect on Household Transmission of Omicron and Delta SARS-CoV-2 Variants
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Kim Yong-Chan
Kim Bong-Young
Son Nak-Hoon
Heo Nam-Woo
Nam Yoo-Ju
Shin A-Reum
Yang Andrew Ji-Hoon
Kim Min-Hyung
Kyong Tae-Young
Kang Ea-Wha
Park Yoon-Soo
Kim Hee-Jung
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Abstract
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Background: We evaluated the household secondary attack rate (SAR) of the omicron and delta severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, according to the vaccination status of the index case and household contacts; further, in vaccinated index cases, we evaluated the effect of the antibody levels on household transmission.
Methods: A prospective cross-sectional study of 92 index cases and 197 quarantined household contacts was performed. Tests for SARS-CoV-2 variant type and antibody level were conducted in index cases, and results of polymerase chain reaction tests (during the quarantine period) were collected from contacts. Association of antibody levels in vaccinated index cases and SAR was evaluated by multivariate regression analysis.
Results: The SAR was higher in households exposed to omicron variant (42%) than in those exposed to delta variant (27%) (P = 0.040). SAR was 35% and 23% for unvaccinated and vaccinated delta variant exposed contacts, respectively. SAR was 44% and 41% for unvaccinated and vaccinated omicron exposed contacts, respectively. Booster dose immunisation of contacts or vaccination of index cases reduced SAR of vaccinated omicron variant exposed contacts. In a model with adjustment, anti-receptor-binding domain antibody levels in vaccinated index cases were inversely correlated with household transmission of both delta and omicron variants. Neutralising antibody levels had a similar relationship.
Conclusion: Immunisation of household members may help to mitigate the current pandemic.
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KEYWORD
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COVID-19, Transmission, SARS-CoV-2, COVID-19 Vaccines, Antibody Level
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